3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration
نویسندگان
چکیده
منابع مشابه
3-D Bioprinting of Innervated Skeletal Muscle Tissue for Accelerated Restoration of Muscle Function
Introduction Recent advances in muscle tissue engineering present a promising solution to achieve functional recovery of volumetric skeletal muscle defects. 1,2 Rapid progress has been made in the development of a bioengineered muscle tissue by combining cells and biomaterials. While the classical tissue engineering approach involving the cellseeded scaffolds produces muscle tissues in vivo, bu...
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Skeletal muscle tissue is characterized by high metabolic requirements, defined structure and high regenerative potential. As such, it constitutes an appealing platform for tissue engineering to address volumetric defects, as proven by recent works in this field. Several issues common to all engineered constructs constrain the variety of tissues that can be realized in vitro, principal among th...
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Berg, H. E., L. Larsson, and P. A. Tesch. Lower limb skeletal muscle function after 6 wk of bed rest. J. Appl. Physiol. 82(1): 182–188, 1997.—Force, electromyographic (EMG) activity, muscle mass, and fiber characteristics were studied in seven healthy men before and after 6 wk of bed rest. Maximum voluntary isometric and concentric knee extensor torque decreased (P , 0.05) uniformly across angu...
متن کاملSkeletal Muscle Function and Metabolism
Skeletal muscle consists of bundles of long spindle shaped cells called muscle fibers that attach to bone by tendinous insertions. The blood vessels and nerves that nourish and control muscle function run in thin sheets of connective tissue that surround bundles of muscle fibers. Each nerve branch communicates with one muscle fiber at the motor end. The nerve and all the muscle fibers that it s...
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Lack of neural innervation due to neurological damage renders muscle unable to produce force. Use of electrical stimulation is a medium in which investigators have tried to find a way to restore movement and the ability to perform activities of daily living. Different methods of applying electrical current to modify neuromuscular activity are electrical stimulation (ES), neuromuscular electrica...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-29968-5